Pearson Edexcel International GCSE in Biology · 4BI1 · Free · no account needed

Cloning Mammals — exam questions

10 original Incandio exam-style questions on Cloning Mammals, 27 marks, about 27 minutes of writing. Each one carries the command word, the tariff and the specification statement it assesses, exactly as a paper presents them. This is an original Incandio practice question, written to reflect the structure and demands of the qualification. It is not an official Pearson Edexcel past-paper question.

This is the practice set for Cloning Mammals — the lesson that teaches it. Read the lesson first if the idea is new; come here when you want to find out whether you can turn it into marks. Completely free, no account needed to read.

What these questions ask of you

7 command words run through this set, and on Pearson Edexcel International GCSE Biology each one means something precise. Answering the wrong command is the commonest way a candidate who understands the lesson still loses the mark.

Which (1 mark)
one option chosen from the set given
State (1 mark)
one precise fact, no justification
Describe (2–4 marks)
developed, linked statements of WHAT happens — no reason required, but detail is Misread as: giving one bare statement where the tariff asked for a developed account
Explain (2–4 marks)
a causal chain — WHY it happens, each link a separate marking point Misread as: describing what happens without giving the reason it happens
Suggest (1–3 marks)
a plausible answer applying taught biology to a situation not taught
Give (1–2 marks)
a short factual answer drawn from recall or from the data
Evaluate (3–6 marks)
evidence on both sides, then a judgement that follows from it

Assessed on Paper 1 (4BI1/1B) and Paper 2 (4BI1/2B), against AO1, AO2, AO3.

Where these sit in the specification

Pearson Edexcel International GCSE Biology (4BI1) — statements 5.19 · 5.20. Incandio is aligned to this specification; it is not published by, endorsed by or affiliated with Pearson, and it reproduces none of Pearson's wording.

The 10 questions

Answer them on paper, then open the lesson's exam practice to have them marked. The mark scheme, the accepted and rejected answers and the annotated model answer are in Incandio and are not printed here — an answer beside its question is not practice.

  1. Table 1 — the three sheep involved in one cloning experiment, and what each contributed.
    SheepBreedContribution
    Pwhite-facedthe udder cell whose nucleus was used
    Qblack-facedthe unfertilised egg cell
    Rblack-facedcarried the embryo to birth

    (a)

    (1)Give

    Give the sheep in Table 1 that the cloned lamb is genetically identical to.

    Table 1 — the three sheep involved in one cloning experiment, and what each contributed.
    SheepBreedContribution
    Pwhite-facedthe udder cell whose nucleus was used
    Qblack-facedthe unfertilised egg cell
    Rblack-facedcarried the embryo to birth

    Specification 5.19 · AO2 + AO3 · about 1 min

    (b)

    (3)Explain

    Explain what the face colour of the cloned lamb would be, and why.

    Table 1 — the three sheep involved in one cloning experiment, and what each contributed.
    SheepBreedContribution
    Pwhite-facedthe udder cell whose nucleus was used
    Qblack-facedthe unfertilised egg cell
    Rblack-facedcarried the embryo to birth

    Specification 5.19 · AO2 + AO3 · about 3 min

    (c)

    (2)Suggest

    Suggest why the scientists deliberately used a white-faced sheep for P and black-faced sheep for Q and R.

    Table 1 — the three sheep involved in one cloning experiment, and what each contributed.
    SheepBreedContribution
    Pwhite-facedthe udder cell whose nucleus was used
    Qblack-facedthe unfertilised egg cell
    Rblack-facedcarried the embryo to birth

    Specification 5.19 · AO3 · about 2 min

    (Total for Question 1 = 6 marks)

  2. (1)Which

    Which is removed from the egg cell before nuclear transfer?

    Structure
    Athe cytoplasm
    Bthe nucleus
    Cthe cell membrane
    Dthe mitochondria

    Specification 5.19 · AO1 · about 1 min

    (Total for Question 2 = 1 mark)

  3. (1)State

    State which animal a cloned mammal is genetically identical to.

    Specification 5.19 · AO1 · about 1 min

    (Total for Question 3 = 1 mark)

  4. (4)Describe

    Describe how a mammal is cloned by nuclear transfer.

    Cloning by nuclear transfer: a body-cell nucleus from sheep A is placed in an emptied egg from sheep B, and the embryo is carried by sheep C
    Figure 1 — cloning a mammal by nuclear transfer.

    Specification 5.19 · AO1 · about 4 min

    (Total for Question 4 = 4 marks)

  5. (3)Explain

    Explain why a nucleus from an adult body cell can direct the development of a whole new animal.

    Specification 5.19 · AO1 + AO2 · about 3 min

    (Total for Question 5 = 3 marks)

  6. (3)Explain

    Explain why cloning is used to produce transgenic animals that make human proteins in their milk.

    Specification 5.20 · AO1 + AO2 · about 3 min

    (Total for Question 6 = 3 marks)

  7. (3)Suggest

    Suggest why a cloned animal is not always completely identical to the animal that supplied the nucleus.

    Specification 5.19 · AO2 · about 3 min

    (Total for Question 7 = 3 marks)

  8. (6)Evaluate

    Evaluate the cloning of farm animals by nuclear transfer as a way of improving a herd.

    Specification 5.19, 5.20 · AO1 + AO2 + AO3 · about 6 min

    (Total for Question 8 = 6 marks)

Have them marked, then defend the answer

Practice tells you the mark; teaching it back tells you whether you understand it. On Incandio a topic counts as mastered only once you have taught it and defended it.

  1. Mark these questions — 10 questions, marked on Incandio against the authored scheme, with the mistake you actually made named.
  2. Teach it — explain Cloning Mammals to Ember, an AI pupil who does not have it yet and asks the awkward question.
  3. Defend it — argue it against Ian Wilmut over three rounds, marked against descriptors you can read first.

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